Neurotoxins: treatment guide
Jeuveau: what it is, results, side effects and cost
What is Jeuveau?
Jeuveau is a prescription injection of prabotulinumtoxinA-xvfs, a botulinum toxin type A approved by the FDA in 2019 for the temporary improvement of moderate to severe frown lines between the eyebrows in adults.[1] It relaxes the injected muscles by blocking the nerve signals that make them contract.[1] In two phase 3 trials, about 7 in 10 people treated had at least a 2-grade improvement in their frown lines at day 30, compared with about 1% on placebo.[1][2]
Jeuveau quick facts
| What it is | Jeuveau (prabotulinumtoxinA-xvfs), a prescription botulinum toxin type A injection[1] |
|---|---|
| What it treats | Temporary improvement of moderate to severe frown lines (glabellar lines) between the brows in adults. It is not approved for any other condition.[1] |
| Results in trials | About 68% to 70% of treated people had at least a 2-grade improvement at day 30, compared with about 1% on placebo[1][2] |
| Label dose for frown lines | 20 units, given as five injections of 4 units each[1] |
| Treatment time | A single office visit; you go home the same day[5] |
| Downtime | Most people return to everyday activities right away after botulinum toxin treatment[4] |
| How often | Retreatment no more often than every three months[1] |
| Cost | Varies by clinic and area. Depends on the amount of product, the areas treated, the provider and location.[6] |
| Insurance | Botulinum toxin treatment for signs of aging is generally not covered[3] |
How Jeuveau works
Jeuveau is a 900 kDa botulinum toxin type A, produced by fermentation of the bacterium Clostridium botulinum.[1] It is one of the common botulinum toxin injections, alongside Botox, Dysport, Xeomin and Daxxify.[6]
When a provider injects it into a muscle, Jeuveau blocks the release of acetylcholine at the nerve endings, the chemical signal that tells the muscle to contract.[1] The treated muscles relax, so the frown lines they create soften, and the effect is temporary.[1][4]
Each vial contains the toxin complex, human serum albumin and sodium chloride.[1] Unlike Botox, which has several cosmetic and medical uses, Jeuveau is approved only for frown lines.[1][7] For a full overview of botulinum toxin treatment, see our Botox guide.
What to expect, step by step
- Before your consultation: preview it in the appIf you like, scan your face in the SkinSync AI app and look at an illustrative neurotoxin simulation, so you can show your provider what you have in mind. The simulation is not specific to Jeuveau, it does not predict your result, and your provider decides what is appropriate for you.
- ConsultationShare your goals, your medical history and a current list of medicines and supplements. Tell your provider if you have had any other botulinum toxin product in the last 4 months.[1] Blood thinners and NSAIDs can increase bruising.[5]
- PreparationYour provider may apply a topical numbing agent to the skin.[5]
- InjectionsFor frown lines, the label dose is 20 units divided into five injections: one in the procerus muscle and two in each corrugator muscle between the brows.[1] The injections can cause some pain.[5] The label notes that needle-related pain or anxiety can occasionally cause fainting or a drop in blood pressure.[1]
- Right afterYou go home the same day, and most people return to everyday activities right away. Ask your provider when you can apply makeup, and take care not to press or rub it in.[4][5]
- ResultsIn the phase 3 trials, differences from placebo were seen from the first check on day 2. The main result was measured at day 30, when 68% and 70% of treated people in the two trials had at least a 2-grade improvement.[1][2]
- MaintenanceAt day 150, the end of the trials, 43% to 57% of treated people were still rated as improved or much improved, depending on the trial and on whether the doctor or the patient was rating.[2] Jeuveau should not be repeated more often than every three months.[1]
Side effects and who should avoid Jeuveau
Common side effects
In the two placebo-controlled trials for frown lines, these side effects were reported more often with Jeuveau than with placebo:[1]
- Headache (12%, compared with 13% on placebo)[1]
- Drooping eyelid (2%, compared with 0%)[1]
- Upper respiratory tract infection (3%, compared with 1%)[1]
- An increased white blood cell count (1%, compared with 0%)[1]
Pain, swelling, redness, tenderness or bruising can also occur where the needle goes in.[1] The label notes that most side effects appear within the first week and, while generally temporary, can last several months or longer.[1] Jeuveau can also cause dry eye; report eye pain, irritation, light sensitivity or vision changes to your provider.[1]
Serious but rare: spread of toxin effect
The FDA label carries a boxed warning: the effect of Jeuveau, like all botulinum toxin products, can spread from the injection area and cause symptoms such as trouble swallowing or breathing, which can be life threatening. These symptoms have been reported hours to weeks after injection.[1] Tell your doctor right away about trouble swallowing, speaking or breathing. If you notice muscle weakness, blurred vision or drooping eyelids, avoid driving and other potentially dangerous activities.[1]
Who should avoid Jeuveau or talk to a provider first
- Allergy to any botulinum toxin product or any ingredient in Jeuveau[1]
- Infection at the planned injection site[1]
- Pregnancy or breastfeeding. It is not known whether Jeuveau can harm an unborn baby or passes into breast milk.[1]
- Neuromuscular disease such as ALS, myasthenia gravis or Lambert-Eaton syndrome, drooping eyelids or weak forehead muscles[1]
- Heart problems, breathing problems, swallowing problems or bleeding problems, past side effects from a botulinum toxin, or past facial surgery[1]
- Under 18. Safety and effectiveness have not been established in children.[1]
Jeuveau contains albumin, a product made from human blood. The label states the risk of passing on a viral disease is extremely remote, and no such cases have been identified for licensed albumin.[1]
Only get Jeuveau from a licensed provider
Do not buy botulinum toxin online, and avoid injections at a non-medical spa, a party, a salon or someone's home, where serious complications have occurred.[4]
Jeuveau aftercare
Follow your own provider's instructions. General advice after botulinum toxin injections includes:[4][5]
- Do not rub or massage the treated areas, especially in the first few hours.[4][5]
- Stay upright for three to four hours after treatment.[5]
- Hold off on strenuous exercise for at least two hours, and follow your own provider's instructions.[4][5]
- Makeup is fine if you apply it gently without pressing or rubbing.[4]
- Watch for warning signs such as trouble swallowing, speaking or breathing, and tell your doctor right away.[1]
Jeuveau vs Botox vs Daxxify
Jeuveau, Botox Cosmetic and Daxxify are all botulinum toxin type A products approved by the FDA for frown lines. They differ in their approved uses, their formulation and how their doses are measured.[1][7][8] Dysport and Xeomin are also FDA approved for frown lines.[9][10]
Swipe sideways to see all three products.
| Jeuveau | Botox Cosmetic | Daxxify | |
|---|---|---|---|
| Active ingredient | prabotulinumtoxinA-xvfs | onabotulinumtoxinA | daxibotulinumtoxinA-lanm |
| Company on the FDA label | Evolus, Inc. | Allergan, Inc. | Revance Therapeutics, Inc. |
| First U.S. approval (any use) | 2019 | 1989 | 2022 |
| FDA-approved uses | Frown lines only (adults) | Cosmetic: frown lines, crow's feet, forehead lines, neck bands (adults) | Frown lines (adults); also cervical dystonia |
| Label dose for frown lines | 20 units | 20 units | 40 units |
| What is in the vial | A 900 kDa toxin complex, with human albumin | The toxin as a complex with accessory proteins, with human albumin | A 150 kDa toxin without accessory proteins, with the RTP004 peptide; no human albumin listed |
| Can units be compared? | No. Each label states that its units are specific to that product and cannot be compared with or converted to units of another botulinum toxin. | ||
| Source | FDA label[1] | FDA label[7] | FDA label[8] |
Jeuveau and Botox Cosmetic share the same label dose for frown lines, but that does not make their units interchangeable.[1][7] Jeuveau's phase 3 trials compared it with placebo.[2] Learn more in our Daxxify guide.
Which product suits you is a decision to make with a licensed provider.
Frequently asked questions about Jeuveau
How long does Jeuveau last?
The label does not state a set duration. In the phase 3 trials, which followed people for 150 days, 43% to 57% of treated people were still rated as improved or much improved at day 150, depending on the trial and the rater.[2] Jeuveau should not be repeated more often than every three months.[1]
How quickly does Jeuveau work?
In the phase 3 trials, differences from placebo were seen from the first check on day 2, and more than 90% of treated people were rated improved or much improved at days 7, 14 and 30.[2]
Is Jeuveau the same as Botox?
No. Both are botulinum toxin type A, but they are different products from different companies. Botox Cosmetic is approved for more cosmetic areas, while Jeuveau is approved only for frown lines. Both labels list 20 units for frown lines, but each label states its units cannot be compared with or converted to another product's units.[1][7]
What is Jeuveau approved for?
Only the temporary improvement of moderate to severe frown lines between the eyebrows in adults.[1] Using it in other areas is an off-label decision for your provider.
How much does Jeuveau cost?
Varies by clinic and area. The cost of botulinum toxin injections depends on how advanced the lines are, the amount of product used, the provider's expertise and the location.[6]
Who should not get Jeuveau?
You should not get Jeuveau if you are allergic to any botulinum toxin product or its ingredients, or if you have an infection where it would be injected. Tell your provider if you are pregnant or breastfeeding, or if you have a nerve and muscle disease, drooping eyelids, weak forehead muscles, or breathing, swallowing, heart or bleeding problems.[1]
What are the most common side effects?
In the frown line trials: headache (12%, similar to 13% on placebo), a drooping eyelid (2%), upper respiratory tract infection (3%) and an increased white blood cell count (1%).[1]
What is the biggest risk of Jeuveau?
The FDA label carries a boxed warning that the effect of any botulinum toxin product can spread beyond the injection site and cause trouble swallowing or breathing, which can be life threatening. Symptoms have been reported hours to weeks after injection.[1]
Can I switch to Jeuveau from another neurotoxin?
That is a decision for your provider. Units are not interchangeable between botulinum toxin products.[1] Tell your provider about any botulinum toxin you received in the last 4 months.[1]
Can I see a Jeuveau simulation in the SkinSync AI app?
The app shows an illustrative neurotoxin simulation that is not specific to any brand, including Jeuveau. You can scan your face, preview treatment of areas such as frown lines, forehead and crow's feet, and then find a clinic and book a consultation. A simulation does not predict results, and a licensed provider decides what is appropriate for you.
SkinSync AI: Aesthetic Care
See a simulation before you book.
Read up here, then use the app to picture a neurotoxin treatment on your own face and take the next step with a clinic. Arrive at your consultation informed and ready to ask the right questions.
- Scan your face and see an illustrative neurotoxin simulation (not specific to Jeuveau) from the front and both sides: forehead, frown lines, crow's feet, lip flip, masseter reduction and more
- Find participating clinics and providers, with availability and pricing
- Book a consultation, in person or virtual, or a treatment in the app
- Save your scans and get reminders and aftercare guidance
Simulations are illustrative and do not predict results. The app does not give medical advice; a licensed provider determines appropriate treatment.
Sources
Every medical fact on this page is linked to one of these sources. Reviewed October 30, 2026.
- FDA approved prescribing information and Medication Guide: JEUVEAU (prabotulinumtoxinA-xvfs), via DailyMed, National Library of Medicine
- Beer KR, et al. Efficacy and safety of prabotulinumtoxinA for the treatment of glabellar lines in adult subjects: results from 2 identical phase III studies. Dermatol Surg. 2019;45(11):1381-1393 (PubMed; free full text on PMC)
- American Academy of Dermatology: Botulinum toxin therapy, overview
- American Academy of Dermatology: Botulinum toxin therapy, FAQs
- Advances in Dermatology and Allergology (Postepy Dermatologii i Alergologii): The whole truth about botulinum toxin: a review (2019); Clinical, Cosmetic and Investigational Dermatology: Botulinum toxin (Botox) A for reducing the appearance of facial wrinkles: a literature review of clinical use and pharmacological aspect (2019)
- American Society of Plastic Surgeons: How much do botulinum toxin injections cost?
- FDA approved prescribing information: BOTOX Cosmetic (onabotulinumtoxinA), via DailyMed
- FDA approved prescribing information and Medication Guide: DAXXIFY (daxibotulinumtoxinA-lanm), via DailyMed, National Library of Medicine
- FDA approved prescribing information: DYSPORT (abobotulinumtoxinA), via DailyMed
- FDA approved prescribing information: XEOMIN (incobotulinumtoxinA), via DailyMed
Related guides
Jeuveau, Botox, Botox Cosmetic, Daxxify, Dysport and Xeomin are trademarks of their respective owners. SkinSync AI is not affiliated with or endorsed by these companies.